Studying the co-evolution of protein families with the Mirrortree web server

Bioinformatics. 2010 May 15;26(10):1370-1. doi: 10.1093/bioinformatics/btq137. Epub 2010 Mar 30.


Summary: The Mirrortree server allows to graphically and interactively study the co-evolution of two protein families, and investigate their possible interactions and functional relationships in a taxonomic context. The server includes the possibility of starting from single sequences and hence it can be used by non-expert users.

Availability and implementation: The web server is freely available at It was tested in the main web browsers. Adobe Flash Player is required at the client side to perform the interactive assessment of co-evolution.


Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Protein
  • Evolution, Molecular*
  • Internet
  • Proteins / chemistry*
  • Sequence Alignment
  • Sequence Analysis, Protein
  • Software*
  • User-Computer Interface


  • Proteins