Minireview: Estrogen receptor-beta: mechanistic insights from recent studies

Mol Endocrinol. 2010 Sep;24(9):1703-14. doi: 10.1210/me.2009-0288. Epub 2010 Apr 2.


The discovery of estrogen receptor-beta (ERbeta) in 1996 stimulated great interest in the physiological roles and molecular mechanisms of ERbeta action. We now know that ERbeta plays a major role in mediating estrogen action in several tissues and organ systems, including the ovary, cardiovascular system, brain, and the immune system, and that ERbeta and ERalpha generally play distinct physiological roles in the body. Although significant progress has been made toward understanding the molecular mechanisms of ERbeta action, particularly in vitro, there remains a large gap in our understanding of the mechanisms by which ERbeta elicits its biological functions in a true physiological context.

Publication types

  • Review

MeSH terms

  • Animals
  • Estrogen Receptor beta / metabolism*
  • Humans
  • Ligands
  • Receptor Cross-Talk
  • Signal Transduction


  • Estrogen Receptor beta
  • Ligands