Treatment of posterior fossa tumors in children

Expert Rev Neurother. 2010 Apr;10(4):525-46. doi: 10.1586/ern.10.28.

Abstract

The most common posterior fossa tumors in children are medulloblastoma, astrocytoma and ependymoma. Atypical rhabdoid teratoid tumors and brain stem gliomas are relatively rare. As the posterior fossa is a limited space, the tumors presenting in this region cause symptoms early on and require prompt treatment to avoid potential morbidity and mortality. Early detection and diagnosis of these tumors and prompt neurosurgical consultation is crucial in the optimum management of pediatric infratentorial brain tumors. Surgery is the mainstay of treatment, as it provides biopsy and decompression of the tumor. Adjuvant therapy is required in the majority of cases. Recent advances in the field of radiation biology and pharmacology have improved dose and delivery techniques of chemoradiation therapy. In the current era, advances in translational research and molecular genetics have assumed a major role in the pursuit of achieving a 'cure' for these potentially malignant tumors.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Child
  • Combined Modality Therapy
  • Humans
  • Infratentorial Neoplasms / therapy*
  • Neurosurgical Procedures / adverse effects
  • Neurosurgical Procedures / methods

Substances

  • Antineoplastic Agents