Antimicrobial and other oligopeptides of grapes

Biochemistry (Mosc). 2010 Feb;75(2):214-23. doi: 10.1134/s0006297910020124.


Structures and functions of about 700 oligopeptides of various plants are presently known. However, only one polypeptide has been isolated from grapes and characterized. At the same time, tens of thousands of uncharacterized amino acid sequences have been revealed in this plant, among which there can also be precursors of oligopeptide regulators. Due to the scientific and practical importance of innate immunity of agricultural plants, we have undertaken structural and functional investigation of these sequences to identify new regulatory oligopeptides including antimicrobial agents. For this purpose, we elaborated a special method of computer analysis enabling comparison of primary structures of putative precursors of grape oligopeptides with amino acid sequences of known oligopeptides of other plants. Structural similarity served as the basis for prediction of potential functional properties. As a result, over 20 new structures of antimicrobial and other grape oligopeptides have been found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / metabolism*
  • Computational Biology*
  • Molecular Sequence Data
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism*
  • Structure-Activity Relationship
  • Vitis / chemistry*


  • Anti-Infective Agents
  • Oligopeptides