Abstract
The chemistry phosphorus and sulfur ylides have been exploited for a facile, short and efficient synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles from E- and Z-isomers of bromo derivatives of Morita-Baylis-Hillman adducts of isatin with Ph(3)P/activated alkene/K(2)CO(3) and Me(2)S/DEAD/K(2)CO(3), respectively, via [3 + 2]-annulation strategy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis
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Alkenes / chemistry*
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Cyclization
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Indoles / chemical synthesis
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Indoles / chemistry*
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Models, Molecular
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Molecular Structure
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Oxindoles
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Spiro Compounds / chemical synthesis*
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Stereoisomerism
Substances
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Alkenes
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Indoles
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Oxindoles
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Pyrazoles
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Spiro Compounds
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2-oxindole