Dianilides of dipicolinic acid function as synthetic chloride channels

Chem Commun (Camb). 2010 Apr 28;46(16):2838-40. doi: 10.1039/b924812a. Epub 2010 Mar 4.


We report that N(2),N(6)-bis(4-nitrophenyl)pyridine-2,6-dicarboxamide, which is related to known isophthalic acid dianilides, transports Cl(-) ions through phospholipid bilayer membranes and shows clear evidence of channel activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anilides / chemistry*
  • Chloride Channels / chemical synthesis
  • Chloride Channels / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Picolinic Acids / chemistry*


  • Anilides
  • Chloride Channels
  • Picolinic Acids
  • dipicolinic acid