Rheumatoid arthritis masquerading as acromegaly recurrence: report of two cases

Rheumatol Int. 2012 Sep;32(9):2913-5. doi: 10.1007/s00296-010-1490-6. Epub 2010 Apr 6.


Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely reported clinical situation in patients with acromegalic. We herein report 57- and 45-year-old two women, who complained bilateral, symmetric pain, swelling and morning stiffness in the joints of hands after optimal acromegaly treatment resembling acromegaly arthropathy. There was not arthralgia in other joints of the patients. Laboratory and radiological evaluations were carried out. After excluding the acromegaly activation and arthropathy by GH and IGF-1 measurement, according to clinical presentation, laboratory and radiological assessments, patients were diagnosed as RA.

Publication types

  • Case Reports

MeSH terms

  • Acromegaly / blood
  • Acromegaly / diagnosis*
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / diagnosis*
  • Diagnosis, Differential
  • Diagnostic Errors
  • Female
  • Growth Hormone / blood
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Middle Aged
  • Recurrence


  • Insulin-Like Growth Factor I
  • Growth Hormone