Anticancer drug development: the grand challenges

Nat Rev Drug Discov. 2010 Apr;9(4):253-4. doi: 10.1038/nrd3144.


Despite vast investment in oncology R&D, the translation of research advances into medicines that substantially improve the treatment of many cancers remains frustratingly slow. What are the key challenges in anticancer drug development, and how might they be addressed?

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Drug Delivery Systems
  • Drug Design*
  • Drug Screening Assays, Antitumor / methods
  • Humans
  • Legislation, Drug
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology
  • Precision Medicine
  • Research


  • Antineoplastic Agents