The fate of the claudicant--a prospective study of 1969 claudicants

Eur J Vasc Surg. 1991 Apr;5(2):131-3. doi: 10.1016/s0950-821x(05)80676-0.


A prospective study of 1969 patients with intermittent claudication receiving placebo medication for a minimum of 1 year is reported. Patients were carefully monitored and only four patients were lost to follow-up. Annual mortality was 4.3%. Thirty-six patients developed a definite myocardial infarction, 27 a major stroke, 32 required a major amputation and 111 required surgical or radiological intervention for deteriorating ischaemia of the leg. The entry characteristics of the patients were analysed as a predictor of serious cardiovascular events. The most sensitive predictors of total mortality were age, history of coronary heart disease and an ankle/arm pressure ratio below 0.5. Of the laboratory measurements performed only the initial white cell count was a significant predictor of myocardial infarction, stroke and vascular deaths.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Amputation, Surgical
  • Cerebrovascular Disorders / epidemiology
  • Double-Blind Method
  • Female
  • Humans
  • Intermittent Claudication / mortality*
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Placebos
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors


  • Placebos