Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans

FEMS Microbiol Lett. 1991 Jan 15;61(2-3):331-4. doi: 10.1016/0378-1097(91)90575-u.

Abstract

Glutathione (GSH) levels were directly monitored by reverse phase HPLC during the thermal yeast-to-mycelial induction of Candida albicans. The GSH levels decreased approximately 100-fold within 120 min which corresponded to the time of maximal yeast-to-mold conversion. The yeast to mold conversion was inhibited by 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one (CDDP), a thiol-specific alkylator, which prevented the decline in GSH levels. These results are discussed with respect to the potential involvement of intracellular GSH levels in regulation of the yeast-to-mold dimorphism in Candida albicans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida albicans / physiology*
  • Glutathione / metabolism*
  • Kinetics
  • Temperature
  • Time Factors

Substances

  • Glutathione