MHC class II (I-A) region control of the IgE antibody repertoire to the ABA-1 allergen of the nematode Ascaris

Immunology. 1991 Apr;72(4):577-9.


ABA-1 is an approximately 14,000 molecular weight (MW) allergen which is among the most abundant proteins synthesized by the nematode parasite Ascaris. IgG and IgE responses to it are major histocompatibility complex (MHC)-restricted in rodents and have only been found to occur in rats of the RT1u haplotype and mice of the H-2s haplotype. Humans infected with the parasite vary substantially in their immune response to the allergen, but the genetic basis for this unknown. H-2 recombinant mice were used to identify the region within the MHC controlling antibody responses to the allergen. IgG antibody to immunoaffinity purified ABA-1 was assayed by radio-immunoassay and IgE by passive cutaneous anaphylaxis. This showed that the restriction element is the I-A molecule and that there was some evidence for I-E modulation of the level of response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / immunology*
  • Animals
  • Antibodies, Helminth / biosynthesis*
  • Antigens, Helminth / immunology
  • Ascaris / immunology*
  • H-2 Antigens / genetics
  • Haplotypes / immunology
  • Histocompatibility Antigens Class II / immunology*
  • Immunoglobulin E / biosynthesis*
  • Immunoglobulin G / biosynthesis
  • Mice
  • Mice, Inbred Strains


  • Allergens
  • Antibodies, Helminth
  • Antigens, Helminth
  • H-2 Antigens
  • Histocompatibility Antigens Class II
  • Immunoglobulin G
  • Immunoglobulin E