Status of oxidative stress in rheumatoid arthritis

Int J Rheum Dis. 2009 Apr;12(1):29-33. doi: 10.1111/j.1756-185X.2009.01375.x.


Aim: To assess the oxidative stress status in rheumatoid arthritis by measuring markers of free radical production, systemic activity of disease, free radical mediated tissue destruction and levels of antioxidant.

Methods: Peripheral blood samples were used for all the assays. Total nitric oxide (NO) was quantitatively measured using immunoassay kit. Malondialdehyde (MDA) and vitamin E were measured by spectrophotometric methods.

Results: Statistically significant changes were observed in the levels of MDA, vitamin E, total NO and erythrocyte sedimentation rate (ESR) in the patient group. Significant differences were also observed in ESR and vitamin E levels in patients with active disease.

Conclusions: Increased oxidative stress status exists, which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / metabolism*
  • Arthritis, Rheumatoid / pathology
  • Arthritis, Rheumatoid / physiopathology
  • Blood Sedimentation
  • Female
  • Free Radicals / blood
  • Health Status
  • Humans
  • Joints / pathology
  • Joints / physiopathology
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Nitric Oxide / blood
  • Oxidative Stress / physiology*
  • Severity of Illness Index
  • Vitamin E / blood
  • Young Adult


  • Free Radicals
  • Vitamin E
  • Nitric Oxide
  • Malondialdehyde