Structure, function, and localization of Gβ5-RGS complexes

Prog Mol Biol Transl Sci. 2009;86:157-203. doi: 10.1016/S1877-1173(09)86006-7. Epub 2009 Oct 7.


Members of the R7 subfamily of regulator of G protein signaling (RGS) proteins (RGS6, 7, 9, and 11) exist as heterodimers with the G protein beta subunit Gβ5. These protein complexes are only found in neurons and are defined by the presence of three domains: DEP/DHEX, Gβ5/GGL, and RGS. This article summarizes published work in the following areas: (1) the functional significance of structural organization of Gβ5-R7 complexes, (2) regional distribution of Gβ5-R7 in the nervous system and regulation of R7 family expression, (3) subcellular localization of Gβ5-R7 complexes, and (4) novel binding partners of Gβ5-R7 proteins. The review points out some contradictions between observations made by different research groups and highlights the importance of using alternative experimental approaches to obtain conclusive information about Gβ5-R7 function in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • GTP-Binding Protein beta Subunits / chemistry*
  • GTP-Binding Protein beta Subunits / metabolism*
  • Humans
  • Protein Binding
  • Protein Structure, Tertiary
  • Protein Transport
  • RGS Proteins / chemistry*
  • RGS Proteins / metabolism*
  • Subcellular Fractions / metabolism


  • GTP-Binding Protein beta Subunits
  • RGS Proteins