The changed metabolic world with human brown adipose tissue: therapeutic visions

Cell Metab. 2010 Apr 7;11(4):268-72. doi: 10.1016/j.cmet.2010.03.007.

Abstract

That adult humans possess active brown adipose tissue potentially leads to a paradigm shift in the understanding of human metabolism and of obesity. Adaptive adrenergic thermogenesis in humans represents brown adipose tissue activity, the absence of which may contribute to middle-age obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue, Brown / physiology*
  • Aging / physiology*
  • Energy Metabolism / physiology*
  • Humans
  • Ion Channels / metabolism*
  • Leptin / metabolism
  • Mitochondrial Proteins / metabolism*
  • Models, Biological
  • Obesity / etiology*
  • Obesity / physiopathology
  • Thermogenesis / physiology*
  • Uncoupling Protein 1

Substances

  • Ion Channels
  • Leptin
  • Mitochondrial Proteins
  • Uncoupling Protein 1