The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response

J Innate Immun. 2009;1(4):335-9. doi: 10.1159/000191216. Epub 2009 Jan 8.


The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / immunology
  • Animals
  • Drosophila Proteins / biosynthesis*
  • Drosophila Proteins / genetics
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / immunology*
  • Female
  • Hemocytes / enzymology
  • Hemocytes / immunology*
  • Immunity, Cellular
  • Immunity, Innate
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Larva / enzymology
  • Larva / immunology
  • Protein-Tyrosine Kinases / biosynthesis*
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics


  • Actins
  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Src64B protein, Drosophila
  • JNK Mitogen-Activated Protein Kinases