Pathophysiology and antioxidant status of patients with fibromyalgia

Rheumatol Int. 2011 Feb;31(2):149-52. doi: 10.1007/s00296-010-1470-x. Epub 2010 Apr 8.


Fibromyalgia syndrome (FMS) is characterized by systemic pain of unknown etiology and is often accompanied by various psychological symptoms. Research on different parameters in fibromyalgia (FM) indicates that multifactors are involved in its pathophysiology; such as genetic factors, substance P, serotonin, hypothalamic pituitary adrenal axis (HPA), muscles metabolic dysfunction, reactive oxygen species (ROS) and reactive nitrogen species (RNS). Oxidative stress has also been implicated in the pathophysiology of FM; therefore, supplementation with antioxidants may be important in modulation of the effects of ROS in patients with FM.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / analysis
  • Antioxidants / metabolism*
  • Antioxidants / therapeutic use
  • Fatigue Syndrome, Chronic / physiopathology
  • Fibromyalgia / genetics
  • Fibromyalgia / physiopathology*
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology
  • Mice
  • Oxidative Stress
  • Pain / metabolism
  • Pain / physiopathology
  • Pituitary-Adrenal System / physiopathology
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / metabolism
  • Substance P / metabolism


  • Antioxidants
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Substance P