[Analysis of the HLA-DPA1 and HLA-DPB1 polymorphism of Zhejiang Han population by PCR-sequence based typing]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Apr;27(2):217-20. doi: 10.3760/cma.j.issn.1003-9406.2010.02.022.
[Article in Chinese]

Abstract

Objective: To investigate the polymorphisms of HLA-DPA1 and HLA-DPB1 loci of Han population in Zhejiang province of China.

Methods: The alleles of HLA-DPA1 and HLA-DPB1 loci in 100 unrelated healthy individuals were analyzed using polymerase chain reaction-sequence based typing.

Results: Eight HLA-DPA1 alleles and 19 HLA-DPB1 alleles were found in the population. The HLA-DPA1 alleles with higher frequencies were DPA1*020202 (47.0%), DPA1*010301 (38.5%) and DPA1*020101(10.5%). The HLA-DPB1 alleles with higher frequencies were DPB1*0501, DPB1*020102 and DPB1*040101. The frequencies were 39.5%, 13.5% and 13.0%, respectively. A total of 44 estimated DPA1-DPB1 haplotypes were detected. The HLA-DPA1*020202-DPB1*0501(29.5%) was the most frequent haplotype.

Conclusion: The polymorphism data of the HLA-DPA1 and -DPB1 were obtained in Han population in Zhejiang province of China. There was linkage disequilibrium between the two loci.

MeSH terms

  • Asian People / ethnology*
  • Asian People / genetics*
  • China / ethnology
  • Databases, Genetic
  • Ethnicity / genetics*
  • Female
  • Gene Frequency
  • Genetic Loci / genetics
  • HLA-DP Antigens / genetics*
  • HLA-DP alpha-Chains
  • HLA-DP beta-Chains
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Male
  • Polymerase Chain Reaction*
  • Polymorphism, Genetic*

Substances

  • HLA-DP Antigens
  • HLA-DP alpha-Chains
  • HLA-DP beta-Chains
  • HLA-DPA1 antigen
  • HLA-DPB1 antigen