Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects

J Transl Med. 2010 Apr 8;8:34. doi: 10.1186/1479-5876-8-34.

Abstract

The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising preclinical and early clinical data for several degenerative conditions, this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days 1, 2, 7, and 14 subsequent to initiation of administration, which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1/CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AC133 Antigen
  • Adult
  • Aged
  • Antigens, CD / metabolism
  • Antigens, CD34 / metabolism
  • Biological Assay
  • Cell Count
  • Cell Movement*
  • Colony-Forming Units Assay
  • Dietary Supplements*
  • Endothelial Cells / cytology*
  • Endothelial Cells / metabolism
  • Erythroid Precursor Cells / cytology
  • Erythroid Precursor Cells / metabolism
  • Glycoproteins / metabolism
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Middle Aged
  • Peptides / metabolism
  • Phenotype
  • Young Adult

Substances

  • AC133 Antigen
  • Antigens, CD
  • Antigens, CD34
  • Glycoproteins
  • PROM1 protein, human
  • Peptides