From the thymus to longevity in the periphery

Curr Opin Immunol. 2010 Jun;22(3):274-8. doi: 10.1016/j.coi.2010.03.003. Epub 2010 Apr 6.


An important attribute of the adaptive immune system is the ability to remember a prior encounter with a pathogen; an ability termed immunological memory. Bigger, better, and stronger responses are mounted upon a secondary encounter with the pathogen potentially resulting in clearance of the infection before the development of disease. We will review recent advances in the field of memory CD8(+) T cell differentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell memory.

Publication types

  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes* / cytology
  • CD8-Positive T-Lymphocytes* / immunology
  • Cell Differentiation / immunology*
  • Humans
  • Immunologic Memory / immunology*
  • Lymphocyte Activation
  • Mice
  • Thymus Gland / cytology
  • Thymus Gland / immunology*