Abstract
A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Combinatorial Chemistry Techniques / methods*
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Cyclization
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Cysteine / chemistry
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Photochemistry
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Sulfhydryl Compounds / chemistry*
Substances
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Peptides, Cyclic
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Sulfhydryl Compounds
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Cysteine