Synthesis of 2-acylfurans from 3-(1-alkynyl)-2-alken-1-ones via the oxidation of gold-carbene intermediates by H2O2

Dalton Trans. 2010 May 14;39(18):4270-3. doi: 10.1039/c0dt00024h.

Abstract

An efficient approach to 2,4,5-trisubstituted 2-acylfurans is described: treating 3-(1-alkynyl)-2-alken-1-ones with AuCl3 in DCM at rt in the presence of H2O2 afforded good yields of 2-acylfurans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Cyclization
  • Furans / chemical synthesis
  • Furans / chemistry*
  • Gold / chemistry*
  • Hydrogen Peroxide / chemistry*
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Oxidation-Reduction

Substances

  • Alkenes
  • Furans
  • carbene
  • Gold
  • Hydrogen Peroxide
  • Methane
  • furan