Hantavirus outbreak associated with laboratory rats in Yunnan, China

Infect Genet Evol. 2010 Jul;10(5):638-44. doi: 10.1016/j.meegid.2010.03.015. Epub 2010 Apr 7.


An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Laboratory / virology*
  • Base Sequence
  • China / epidemiology
  • Disease Outbreaks
  • Disease Vectors
  • Hantaan virus / classification
  • Hantaan virus / genetics*
  • Hemorrhagic Fever with Renal Syndrome / epidemiology*
  • Hemorrhagic Fever with Renal Syndrome / genetics*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / analysis
  • Rats
  • Recombination, Genetic
  • Sequence Analysis, DNA
  • Universities
  • Young Adult
  • Zoonoses*


  • RNA, Viral