Acute extrapyramidal disorder with bilateral reversible basal ganglia lesions in a diabetic uremic patient: diffusion-weighted imaging and spectroscopy findings

J Neurol Sci. 2010 Jun 15;293(1-2):119-21. doi: 10.1016/j.jns.2010.03.001. Epub 2010 Apr 8.


Acute movement disorders associated with bilateral lesions in the basal ganglia are increasingly described in patients affected by diabetes and uremia. Pathophysiology has not been utterly understood yet, but it is likely to be multifactorial, with both ischemic/microvascular and metabolic/toxic factors determining the lesions and symptoms. We have studied a uremic diabetic patient who was admitted in emergency after presenting choreic movements, in which CT and MR, including diffusion-weighted imaging and spectroscopy, showed bilateral symmetric basal ganglia lesions with regression at follow-up. This is the first report in the literature describing spectroscopic findings in this condition.

Publication types

  • Case Reports

MeSH terms

  • Basal Ganglia / pathology*
  • Basal Ganglia Diseases / complications*
  • Diabetes Mellitus / physiopathology*
  • Diffusion Magnetic Resonance Imaging / methods
  • Humans
  • Male
  • Middle Aged
  • Spectrum Analysis / methods
  • Uremia / complications*