E. Coli-Mediated Gut Inflammation in Genetically Predisposed Crohn's Disease Patients

Pathol Biol (Paris). 2013 Oct;61(5):e65-9. doi: 10.1016/j.patbio.2010.01.004. Epub 2010 Apr 8.

Abstract

Many advances have been made in the understanding of Crohn's disease (CD) pathogenesis over the last decade. In CD patients abnormal ileal bacterial colonization could be linked to inappropriate innate immune responses to invasive bacteria. Adherent and invasive Escherichia coli strains have been isolated from CD patients and are able to adhere to and to invade intestinal epithelial cells and to induce colitis in transgenic mice expressing the human CEACAM6 molecule. In this review, we report recent advances concerning the involvement of adherent-invasive E. coli in the aetiology of CD and analyze how they can initiate inflammation of the gut mucosa in individuals with genetic predisposition.

Keywords: CEACAM6; Crohn’ disease; E. coli; Genetic predisposition; Maladie de Crohn; Prédisposition génétique.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / genetics
  • Antigens, CD / physiology
  • Bacterial Adhesion
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / physiology
  • Colitis / microbiology
  • Crohn Disease / genetics*
  • Crohn Disease / immunology
  • Crohn Disease / microbiology*
  • Escherichia coli / immunology
  • Escherichia coli / isolation & purification
  • Escherichia coli / physiology*
  • Escherichia coli Infections / genetics
  • Escherichia coli Infections / microbiology
  • GPI-Linked Proteins / genetics
  • GPI-Linked Proteins / physiology
  • Genetic Predisposition to Disease
  • Humans
  • Ileum / microbiology
  • Inflammation / microbiology*
  • Intestinal Mucosa / microbiology
  • Irritable Bowel Syndrome / microbiology
  • Mice
  • Mice, Transgenic

Substances

  • Antigens, CD
  • CEACAM6 protein, human
  • Cell Adhesion Molecules
  • GPI-Linked Proteins