PTP1B: a double agent in metabolism and oncogenesis

Trends Biochem Sci. 2010 Aug;35(8):442-9. doi: 10.1016/j.tibs.2010.03.004. Epub 2010 Apr 8.


PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Cell Transformation, Neoplastic*
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus / pathology
  • Humans
  • Molecular Targeted Therapy*
  • Obesity / drug therapy
  • Obesity / metabolism*
  • Obesity / pathology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology


  • Protein Tyrosine Phosphatase, Non-Receptor Type 1