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Review
. 2010 Sep;30(2):301-12.
doi: 10.1016/j.reprotox.2010.03.011. Epub 2010 Apr 8.

Possible Endocrine Disrupting Effects of Parabens and Their Metabolites

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Review

Possible Endocrine Disrupting Effects of Parabens and Their Metabolites

Julie Boberg et al. Reprod Toxicol. .

Abstract

Parabens are preservatives used in a wide range of cosmetic products, including products for children, and some are permitted in foods. However, there is concern for endocrine disrupting effects. This paper critically discusses the conclusions of recent reviews and original research papers and provides an overview of studies on toxicokinetics. After dermal uptake, parabens are hydrolyzed and conjugated and excreted in urine. Despite high total dermal uptake of paraben and metabolites, little intact paraben can be recovered in blood and urine. Paraben metabolites may play a role in the endocrine disruption seen in experimental animals and studies are needed to determine human levels of parabens and metabolites. Overall, the estrogenic burden of parabens and their metabolites in blood may exceed the action of endogenous estradiol in childhood and the safety margin for propylparaben is very low when comparing worst-case exposure to NOAELs from experimental studies in rats and mice.

Comment in

  • Reproductive effects of the parabens.
    Scialli AR. Scialli AR. Reprod Toxicol. 2011 Jul;32(1):138-40; author reply 141. doi: 10.1016/j.reprotox.2011.03.005. Epub 2011 Mar 31. Reprod Toxicol. 2011. PMID: 21440055 No abstract available.

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