Host responses to Candida albicans: Th17 cells and mucosal candidiasis

Microbes Infect. 2010 Jul;12(7):518-27. doi: 10.1016/j.micinf.2010.03.013. Epub 2010 Apr 8.

Abstract

Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immunocompromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Candida albicans / immunology*
  • Candidiasis / immunology*
  • Candidiasis / metabolism
  • Cell Line
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate
  • Interleukin-17 / metabolism*
  • Interleukin-23 / metabolism
  • Interleukins / metabolism
  • Models, Animal
  • Mucous Membrane / immunology*
  • Mucous Membrane / metabolism
  • Mucous Membrane / microbiology
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Interleukin-17
  • Interleukin-23
  • Interleukins
  • interleukin-22