Lactic acidosis: recognition, kinetics, and associated prognosis

Crit Care Clin. 2010 Apr;26(2):255-83, table of contents. doi: 10.1016/j.ccc.2009.12.007.


Lactic acidosis is a common condition encountered by critical care providers. Elevated lactate and decreased lactate clearance are important for prognostication. Not all lactate in the intensive care unit is due to tissue hypoxia or ischemia and other sources should be evaluated. Lactate, in and of itself, is unlikely to be harmful and is a preferred fuel for many cells. Treatment of lactic acidosis continues to be aimed the underlying source.

Publication types

  • Review

MeSH terms

  • Acidosis, Lactic / blood
  • Acidosis, Lactic / diagnosis
  • Acidosis, Lactic / metabolism*
  • Humans
  • Lactic Acid / blood
  • Lactic Acid / metabolism*
  • Prognosis


  • Lactic Acid