Surgical technique and results of tracheal and carinal replacement with aortic allografts for salivary gland-type carcinoma

J Thorac Cardiovasc Surg. 2010 Aug;140(2):387-393.e2. doi: 10.1016/j.jtcvs.2010.01.043. Epub 2010 Apr 9.


Objective: We describe the surgical technique and peroperative management of tracheal and carinal replacement with aortic allografts for large salivary gland-type carcinoma and report the results with a mean 34 months' follow-up.

Methods: We performed tracheal and carinal replacements with aortic allografts in 6 patients with extensive mucoepidermoid (n = 1) or adenoid cystic (n = 5) carcinomas. Tracheal tumor resection was followed by carinal restitution (n = 3) and interposition of the graft, splinted by a silicone stent. The allograft consisted of an aortic segment, either fresh (in the first 2 patients) or cryopreserved (in the last 4). All grafts were wrapped with bulky and well-vascularized flaps (pectoral muscle flap all patients, with an additional "thymopericardial fat flap" in the last 2) to promote revascularization and to prevent erosion of adjacent large vessels or fistulas. No immunosuppressive therapy was administered.

Results: Complete resection (R0) was achieved in 5 (83%) of 6 patients. Three of the first 4 patients experienced major morbidity, mainly fistulas between the esophagus and graft. The last 2 patients had an uneventful outcome. All grafts transformed into well-vascularized conduits focally lined with respiratory epithelium. So far, the last 4 patients are disease-free and 3 of them have returned to full-time employment. Stent removal has not been attempted in any patient.

Conclusion: Tracheal replacement with aortic allografts enables resection of extensive tumors with a curative intent. Efficient protective wrap around the graft is mandatory. Further follow-up is required to determine whether cartilage rings are generated within the graft, as in animal models.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aorta, Thoracic / transplantation*
  • Carcinoma, Adenoid Cystic / pathology
  • Carcinoma, Adenoid Cystic / surgery*
  • Carcinoma, Mucoepidermoid / pathology
  • Carcinoma, Mucoepidermoid / surgery*
  • Cryopreservation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neovascularization, Physiologic
  • Pectoralis Muscles / blood supply
  • Pectoralis Muscles / surgery
  • Stents
  • Surgical Flaps
  • Thoracic Surgical Procedures* / adverse effects
  • Thoracic Surgical Procedures* / instrumentation
  • Time Factors
  • Trachea / pathology
  • Trachea / surgery*
  • Tracheal Neoplasms / pathology
  • Tracheal Neoplasms / surgery*
  • Tracheoesophageal Fistula / etiology
  • Transplantation, Homologous
  • Treatment Outcome