Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents

Bioorg Med Chem Lett. 2010 May 1;20(9):2718-21. doi: 10.1016/j.bmcl.2010.03.079. Epub 2010 Mar 25.


Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on approximately 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / chemistry*
  • Cell Line
  • Drug Carriers
  • Gold / chemistry*
  • HIV Envelope Protein gp120 / chemistry
  • HIV Envelope Protein gp120 / metabolism
  • HIV Infections / prevention & control
  • Humans
  • Ligands*
  • Metal Nanoparticles / chemistry*
  • Sulfates / chemistry*
  • Surface Plasmon Resonance


  • Anti-HIV Agents
  • Drug Carriers
  • HIV Envelope Protein gp120
  • Ligands
  • Sulfates
  • Gold