Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells

Neurosci Lett. 2010 May 31;476(2):70-3. doi: 10.1016/j.neulet.2010.04.005. Epub 2010 Apr 9.

Abstract

Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) significantly increased the frequency of spike-dependant spontaneous IPSCs whereas spike-independent mIPSCs remained unchanged. It was suggested that Noopept mediates its effect due to the activation of inhibitory interneurons terminating on CA1 pyramidal cells. Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • CA1 Region, Hippocampal / drug effects*
  • CA1 Region, Hippocampal / physiology
  • Dipeptides / pharmacology*
  • In Vitro Techniques
  • Inhibitory Postsynaptic Potentials
  • Interneurons / drug effects
  • Interneurons / physiology
  • Nootropic Agents / pharmacology*
  • Patch-Clamp Techniques
  • Pyramidal Cells / drug effects*
  • Pyramidal Cells / physiology
  • Rats
  • Rats, Wistar
  • Synaptic Transmission / drug effects*

Substances

  • Anti-Anxiety Agents
  • Dipeptides
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly