Dietary Patterns and Risk of Stomach Cancer Mortality: The Japan Collaborative Cohort Study

Ann Epidemiol. 2010 May;20(5):356-63. doi: 10.1016/j.annepidem.2010.02.002.


Purpose: We sought to examine associations between dietary patterns and the risk of stomach cancer mortality in a cohort study in Japan.

Methods: Factor analysis on food frequency questionnaire was conducted among 25,730 males and 37,673 females in a cohort study in Japan; we identified three dietary patterns, termed "vegetable"; "animal food"; and "dairy product". The Cox proportional hazards model was used to estimate the hazard ratio (HR) with stomach cancer mortality.

Results: The "vegetable" pattern showed no association with stomach cancer mortality in either sex. The "dairy product" pattern was significantly associated with a decreased risk of stomach cancer in males, with multivariate HRs of 0.82 (95% confidence interval [CI]: 0.61-1.10), 0.74 (95% CI: 0.54-1.01), and 0.72 (95% CI: 0.52-0.99) for the second, third, and fourth quartiles, respectively. In addition, the "animal food" pattern tended to be associated with an increased risk in females, but non-significant, with HRs for respective quartiles of 1.45 (95% CI: 0.92-2.29), 1.32 (95% CI: 0.81-2.16), and 1.51 (95% CI: 0.78-2.21).

Conclusions: A diet high in dairy products may be associated with a decreased risk of stomach cancer mortality in males. We did not observe any significant association of this condition with other dietary patterns in either sex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Cohort Studies
  • Confidence Intervals
  • Dairy Products / statistics & numerical data*
  • Factor Analysis, Statistical
  • Feeding Behavior*
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Meat / statistics & numerical data
  • Middle Aged
  • Multivariate Analysis
  • Nutritional Status*
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Statistics, Nonparametric
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / mortality*
  • Surveys and Questionnaires
  • Vegetables