Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

J Lipid Res. 2010 Aug;51(8):2018-31. doi: 10.1194/jlr.R001131. Epub 2010 Apr 9.


Retinal degenerative diseases result in retinal pigment epithelial (RPE) and photoreceptor cell loss. These cells are continuously exposed to the environment (light) and to potentially pro-oxidative conditions, as the retina's oxygen consumption is very high. There is also a high flux of docosahexaenoic acid (DHA), a PUFA that moves through the blood stream toward photoreceptors and between them and RPE cells. Photoreceptor outer segment shedding and phagocytosis intermittently renews photoreceptor membranes. DHA is converted through 15-lipoxygenase-1 into neuroprotectin D1 (NPD1), a potent mediator that evokes counteracting cell-protective, anti-inflammatory, pro-survival repair signaling, including the induction of anti-apoptotic proteins and inhibition of pro-apoptotic proteins. Thus, NPD1 triggers activation of signaling pathway/s that modulate/s pro-apoptotic signals, promoting cell survival. This review provides an overview of DHA in photoreceptors and describes the ability of RPE cells to synthesize NPD1 from DHA. It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Docosahexaenoic Acids / chemistry
  • Docosahexaenoic Acids / metabolism*
  • Humans
  • Nerve Growth Factors / metabolism
  • Oxidative Stress
  • Photoreceptor Cells / cytology*
  • Photoreceptor Cells / metabolism*
  • Retinal Pigment Epithelium / blood supply
  • Retinal Pigment Epithelium / cytology
  • Retinal Pigment Epithelium / metabolism


  • Nerve Growth Factors
  • protectin D1
  • Docosahexaenoic Acids