Applications of elastin-like polypeptides in tissue engineering

Adv Drug Deliv Rev. 2010 Dec 30;62(15):1479-85. doi: 10.1016/j.addr.2010.04.002. Epub 2010 Apr 10.


Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Elastin / chemistry*
  • Humans
  • Peptides / chemistry*
  • Tissue Engineering / methods*


  • Peptides
  • Elastin