Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women

J Strength Cond Res. 2010 May;24(5):1199-207. doi: 10.1519/JSC.0b013e3181d82f8b.


The purpose of the present study was to evaluate the effects of cycle ergometry high-intensity interval training (HIIT) with and without beta-alanine supplementation on maximal oxygen consumption rate (VO2 peak), cycle ergometer workload at the ventilatory threshold (VT W), and body composition. Forty-four women (mean +/- SD age = 21.8 +/- 3.7 years; height = 166.5 +/- 6.6 cm; body mass (BM) = 65.9 +/- 10.8 kg; VO2 peak = 31.5 +/- 6.2 ml x kg(-1) x min(-1)) were randomly assigned to 1 of 3 groups: beta-alanine (BA, n = 14) 1.5 g + 15 g dextrose powder; placebo (PL, n = 19) 16.5 g dextrose powder; or control (CON, n = 11). Testing was conducted at baseline (week 0), after 3 weeks (week 4), and after 6 weeks (week 8). VO2 peak (ml x kg(-1) x min(-1)) and VT W were measured with a metabolic cart during graded exercise tests on a corival cycle ergometer, and body composition (percent fat = % fat and fat-free mass = FFM) were determined by air displacement plethysmography. High-intensity interval training was performed on a corival cycle ergometer 3 times per week with 5 2-minute work intervals and 1-minute passive recovery with undulating intensities (90-110% of the workload recorded at VO2 peak) during each training session. VO2 peak increased (p <or= 0.05) in the BA and PL groups at weeks 4 and 8, but did not change (p > 0.05) for the CON group. VT W increased (p <or= 0.05) for all groups at weeks 4 and 8. Body mass increased (p <or= 0.05) only for the BA group at weeks 4 and 8, whereas %fat decreased (p <or= 0.05) and FFM increased (p <or= 0.05) at weeks 4 and 8 for all groups (BA, PL, and CON). Although it is unclear why beta-alanine supplementation increased BM, there was no additive effects for increasing VO2 peak beyond the PL. Overall, these results suggested that HIIT may be an effective and time-efficient method of training to improve maximal oxygen uptake.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anaerobic Threshold
  • Bicycling / physiology*
  • Body Composition
  • Dietary Supplements*
  • Double-Blind Method
  • Exercise Test
  • Female
  • Humans
  • Oxygen Consumption
  • Physical Education and Training / methods*
  • Physical Endurance*
  • Physical Fitness*
  • beta-Alanine / pharmacology*


  • beta-Alanine