Abstract
Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Catalysis
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Imines / chemical synthesis
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Imines / chemistry*
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Indoles / chemistry*
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Stereoisomerism