Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of L-methionine as a candidate drug cargo

Xingmao Jiang; Timothy L Ward; Yung-Sung Cheng; Juewen Liu; C Jeffrey Brinker

doi:10.1039/b927025f

Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of L-methionine as a candidate drug cargo

Chem Commun (Camb). 2010 May 7;46(17):3019-21. doi: 10.1039/b927025f. Epub 2010 Mar 25.

Authors

Xingmao Jiang¹, Timothy L Ward, Yung-Sung Cheng, Juewen Liu, C Jeffrey Brinker

Affiliation

¹ Department of Chemical and Nuclear Engineering and Center for Micro-Engineered Materials, The University of New Mexico, Albuquerque, NM 87131, USA.

PMID: 20386854
DOI: 10.1039/b927025f

Abstract

Hollow spherical nanoparticles with ordered mesoporous silica shells were fabricated by evaporation-induced self-assembly using (NH(4))(2)SO(4) and cetyltrimethyl ammonium bromide (CTAB) as templates. The model drug, L-methionine, was encapsulated within the spherical void at high loadings by repeated crystallization.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aerosols / chemistry*
Cetrimonium
Cetrimonium Compounds / chemistry
Crystallization
Drug Carriers
Methionine / administration & dosage
Methionine / chemistry*
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Porosity
Silicon Dioxide / chemistry*

Substances

Aerosols
Cetrimonium Compounds
Drug Carriers
Silicon Dioxide
Methionine
Cetrimonium