Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever

Rheumatol Int. 2012 Oct;32(10):3277-9. doi: 10.1007/s00296-010-1474-6. Epub 2010 Apr 13.


Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. The serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease. Although colchicine is effective in the majority of patients, there is no established treatment for those who are resistant or intolerant to colchicine. We herein report the efficacy of anakinra in a 52-year-old Turkish patient with FMF, secondary amyloidosis and renal transplant, who was resistant to colchicine treatment.

Publication types

  • Case Reports

MeSH terms

  • Amyloidosis / etiology
  • Amyloidosis / therapy
  • Anti-Inflammatory Agents / therapeutic use*
  • Colchicine / therapeutic use*
  • Drug Resistance*
  • Familial Mediterranean Fever / complications
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / drug therapy*
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / therapeutic use*
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation
  • Middle Aged
  • Treatment Failure


  • Anti-Inflammatory Agents
  • Interleukin 1 Receptor Antagonist Protein
  • Colchicine