The first provocative test for coronary artery spasm at the Cleveland Clinic

Am J Cardiol. 2010 Apr 15;105(8):1198-9. doi: 10.1016/j.amjcard.2009.12.013.

Abstract

This article provides narration of the events during the development of ergonovine maleate infusions for detecting coronary artery spasm at the Cleveland Clinic in 1973. This was the first safe, reproduceable and reliable test for angiographic visualization of the pathophysiology associated with the Prinzmetal Syndrome termed "angina inversa".

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angina Pectoris, Variant / diagnosis
  • Coronary Angiography
  • Coronary Vasospasm / diagnosis*
  • Coronary Vessels / drug effects
  • Coronary Vessels / physiopathology
  • Diagnosis, Differential
  • Echocardiography
  • Electrocardiography
  • Ergonovine* / administration & dosage
  • Female
  • Hospitals, Teaching*
  • Humans
  • Infusions, Intravenous
  • Ohio
  • Oxytocics / administration & dosage
  • Reproducibility of Results
  • Vasoconstriction

Substances

  • Oxytocics
  • Ergonovine