Continuous glucose monitoring in subjects after simultaneous pancreas-kidney and kidney-alone transplantation

Diabetes Technol Ther. 2010 May;12(5):347-51. doi: 10.1089/dia.2009.0157.


Background: Simultaneous pancreas-kidney (SPK) transplantation is an important replacement therapy for individuals with diabetes and end-stage renal disease. Kidney-alone (KA) transplantation is associated with a high incidence of post-transplant diabetes.

Methods: This was a cross-sectional study. We studied 48-h glucose concentrations in eight subjects with type 1 diabetes mellitus after SPK transplantation, six subjects post-KA transplantation, and nine healthy controls using the CGMS (Medtronic Minimed, Northridge, CA) continuous glucose monitoring system.

Results: The 48-h mean glucose concentration was 101 +/- 7 mg/dL in the SPK subjects, 105 +/- 12 mg/dL in the KA subjects, and 99 +/- 7 mg/dL in the healthy controls. The glycemic excursions were higher in the KA group compared to the SPK cohort and healthy controls (P < 0.0001). No differences in the incidence of hypoglycemia were detected among the three groups. Significant postprandial hyperglycemia was uncovered in four of the six KA subjects.

Conclusions: SPK transplantation is very effective at normalizing glycemic excursions. Unsuspected hyperglycemia was identified in the KA group. The CGMS was a useful ambulatory tool to study glucose profiles in the post-transplant period and may help uncover hyperglycemia undetected by routine laboratory testing.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Area Under Curve
  • Blood Glucose / analysis*
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / surgery
  • Female
  • Humans
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Monitoring, Ambulatory*
  • Pancreas Transplantation*


  • Blood Glucose