In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses

P Selvam; N Murgesh; M Chandramohan; E De Clercq; E Keyaerts; L Vijgen; P Maes; J Neyts; M V Ranst

doi:10.4103/0250-474X.40339

In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses

Indian J Pharm Sci. 2008 Jan;70(1):91-4. doi: 10.4103/0250-474X.40339.

Authors

P Selvam¹, N Murgesh, M Chandramohan, E De Clercq, E Keyaerts, L Vijgen, P Maes, J Neyts, M V Ranst

Affiliation

¹ Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India.

Abstract

4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mug/ml, without toxicity at a concentration up to 42 mug/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.

Keywords: HCV; Isatin; SARS-CoV; huh 5-2 cells; vero cells.