Abstract
A recent study shows that one of the two known Caenorhabditis elegans homologs of the mammalian integrin alpha subunit plays an essential role in the clearance of apoptotic cells - efferocytosis - during nematode development. These new findings reveal that integrins have evolutionarily conserved functions in efferocytosis in metazoans.
MeSH terms
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Animals
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Apoptosis / genetics
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Apoptosis / physiology*
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Caenorhabditis elegans / cytology
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / physiology
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Humans
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Integrin alpha Chains / genetics
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Integrin alpha Chains / physiology
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Integrins / genetics
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Integrins / physiology*
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Models, Biological
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Phagocytosis / physiology
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Signal Transduction
Substances
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Caenorhabditis elegans Proteins
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Integrin alpha Chains
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Integrins