Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract

J Allergy Clin Immunol. 2010 Jul;126(1):3-13; quiz 14-5. doi: 10.1016/j.jaci.2010.01.055. Epub 2010 Apr 14.


Eosinophils are multifunctional leukocytes that increase in various tissues in patients with a variety of disorders. Locally, they can be involved in the initiation and propagation of diverse inflammatory responses. In this review the clinical association of eosinophils with diseases of the skin, lung, and gastrointestinal tract is summarized. An approach to determining the causal role of eosinophils in these diseases is presented. Recent findings concerning molecular diagnosis, cause, and treatment are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Asthma / etiology
  • Cellulitis / etiology
  • Dermatitis, Atopic / etiology
  • Eosinophilia / etiology*
  • Eosinophils / physiology*
  • Esophagitis / etiology
  • Gastrointestinal Diseases / etiology*
  • Humans
  • Hypereosinophilic Syndrome / etiology
  • Organ Specificity
  • Pulmonary Eosinophilia / etiology*
  • Skin Diseases / etiology*