Detection of inducible clindamycin resistance in beta-hemolytic streptococci by using the CLSI broth microdilution test and erythromycin-clindamycin combinations

J Clin Microbiol. 2010 Jun;48(6):2275-7. doi: 10.1128/JCM.00663-10. Epub 2010 Apr 14.

Abstract

This study assessed an erythromycin-clindamycin (ERY-CC) broth test for inducible CC resistance in beta-hemolytic streptococci. One hundred one isolates of groups A, B, C, F, and G were tested by the CLSI broth microdilution method. Combinations of 1 and 0.25 microg/ml or 0.5 and 0.25 microg/ml of ERY and CC, respectively, detected all inducible isolates.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Clindamycin / pharmacology*
  • Drug Resistance, Bacterial*
  • Erythromycin / pharmacology*
  • Hemolysin Proteins / metabolism
  • Humans
  • Microbial Sensitivity Tests / methods
  • Streptococcus / drug effects*
  • Streptococcus / physiology
  • Transcriptional Activation

Substances

  • Anti-Bacterial Agents
  • Hemolysin Proteins
  • Clindamycin
  • Erythromycin