Oxygen in acute and chronic wound healing

Br J Dermatol. 2010 Aug;163(2):257-68. doi: 10.1111/j.1365-2133.2010.09804.x. Epub 2010 Apr 15.


Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defence, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not yet completely understood, many experimental and clinical observations have shown wound healing to be impaired under hypoxia. This article provides an overview on the role of oxygen in wound healing and chronic wound pathogenesis, a brief insight into systemic and topical oxygen treatment, and a discussion of the role of wound tissue oximetry. Thus, the aim is to improve the understanding of the role of oxygen in wound healing and to advance our management of wound patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Administration, Topical
  • Cell Proliferation
  • Humans
  • Hyperbaric Oxygenation / methods
  • Inflammation / physiopathology
  • Oxygen / administration & dosage
  • Oxygen / metabolism
  • Oxygen / therapeutic use*
  • Wound Healing / physiology*
  • Wounds and Injuries / metabolism
  • Wounds and Injuries / physiopathology
  • Wounds and Injuries / therapy*


  • Oxygen