[Studies on gamma-oryzanol. III. Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (author's transl)]

Nihon Yakurigaku Zasshi. 1977 May;73(4):457-63.
[Article in Japanese]


In the course of investigations of gamma-oryzanol in rats, circadian rhythms in antiulcerogenic action on gamma-oryzanol were observed. Circadian rhythms in several other parameters were investigated and correlated with the antiulcerogenic action. Pretreatment of rats with gamma-oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion, and to increase serum 11-OHCS. Suppresive patterns of serum gastrin and gastric secretion following the pretreatment with gamma-oryzanol corresponded to the circadian rhythms in antiulcerogenic action of gamma-oryzanol. A complication of our results suggests that increment of catecholamines in rat brain after gamma-oryzanol plays a role in the above mentioned actions.

MeSH terms

  • 11-Hydroxycorticosteroids / blood*
  • Animals
  • Atropine / pharmacology
  • Circadian Rhythm / drug effects*
  • Gastric Juice / metabolism*
  • Gastrins / blood*
  • Hydrogen-Ion Concentration
  • Male
  • Nialamide / pharmacology
  • Phenylpropionates / pharmacology*
  • Rats
  • Reserpine / pharmacology


  • 11-Hydroxycorticosteroids
  • Gastrins
  • Phenylpropionates
  • Atropine
  • Reserpine
  • Nialamide