Abstract
Minzenberg et al. (Reports, 12 December 2008, p. 1700) and Schmidt et al. (Reports, 24 April 2009, p. 516) reported blood oxygen level-dependent (BOLD) responses in the human locus coeruleus (LC). Here, we show that these LC responses do not correspond to the anatomical location of the LC and present cautionary data concerning the quality of BOLD signals measured from the LC using standard functional magnetic resonance imaging acquisition parameters.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Attention
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Benzhydryl Compounds / pharmacology
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Brain Mapping
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Brain Stem / anatomy & histology
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Central Nervous System Stimulants / pharmacology
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Homeostasis
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Humans
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Locus Coeruleus / anatomy & histology*
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Locus Coeruleus / drug effects
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Locus Coeruleus / physiology*
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Magnetic Resonance Imaging
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Melanins / analysis
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Modafinil
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Neurons / drug effects
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Neurons / physiology
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Oxygen / blood
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Sleep
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Suprachiasmatic Nucleus / physiology
Substances
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Benzhydryl Compounds
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Central Nervous System Stimulants
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Melanins
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neuromelanin
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Modafinil
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Oxygen