Complexes of angiotensin IV with functionally different proteins in the regulation of drinking behavior and hemodynamics in rats

Bull Exp Biol Med. 2009 Nov;148(5):738-41. doi: 10.1007/s10517-010-0805-7.

Abstract

We compared physiological activity of synthetic complexes from angiotensin IV and functionally different proteins (transport protein, bovine serum albumin; and neurospecific Ca(2+)-binding protein, S100b) as model analogues of endogenous protein-peptide complexes. Physiological activity of angiotensin IV was specifically modified by these proteins. Our results suggest that complexes of angiotensin IV with bovine serum albumin and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / analogs & derivatives*
  • Angiotensin II / metabolism
  • Angiotensin II / pharmacology
  • Animals
  • Behavior, Animal / drug effects
  • Blood Pressure / drug effects
  • Cattle
  • Drinking Behavior / drug effects*
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Male
  • Multiprotein Complexes* / metabolism
  • Multiprotein Complexes* / pharmacology
  • Proteins* / metabolism
  • Proteins* / pharmacology
  • Rats
  • Rats, Wistar

Substances

  • Multiprotein Complexes
  • Proteins
  • Angiotensin II
  • angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-