Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement?

Dig Dis Sci. 2010 Dec;55(12):3415-22. doi: 10.1007/s10620-010-1209-2. Epub 2010 Apr 17.


Background: Few studies have explored the satisfaction with proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD).

Aim: The aim of this study was to assess patient and physician satisfaction with currently prescribed PPIs for patients with GERD.

Methods: Separate online surveys were completed by 1,002 physicians and 1,013 GERD patients. Physician surveys examined satisfaction, symptom relief, long-term therapy, side-effects, breakthrough symptoms, and use of supplemental medications with PPIs. Patient surveys evaluated PPI regimen, length of therapy, satisfaction with PPI, symptom relief, use of supplemental medications, and perceptions about long-term use and side-effects.

Results: Most respondents were satisfied with PPI therapy, but 35.4% of GERD patients and 34.8% of physicians perceived patients as "somewhat satisfied" to "completely dissatisfied" with PPI therapy. Patients who were highly satisfied were more likely to indicate complete symptom relief (P < 0.001) relative to patients who were less satisfied. However, over 35% of patients on once-daily and 54% on twice-daily PPI indicated that therapy failed to completely relieve symptoms. Patients who were highly satisfied were more likely to recommend medication to patients with the same symptoms (P < 0.001) and less likely to report that the medication is too expensive (P < 0.001), worry about long-term use (P < 0.001), or add OTC medications for supplemental control (P < 0.004).

Conclusions: Approximately one-third of GERD patients reported persistent symptoms and were dissatisfied with PPI therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Patient Satisfaction*
  • Proton Pump Inhibitors / administration & dosage
  • Proton Pump Inhibitors / therapeutic use*
  • Treatment Outcome


  • Proton Pump Inhibitors