L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline

CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. doi: 10.1017/s1092852900027589.

Abstract

Neuroinflammatory oxidative stress occurs early in AD pathology. Elevated blood Hcy is a useful marker for such neuroinflammation. Hcy contributes to pathological cascades involving AP and NFTs. In AD, Hcy should be lowered by B-vitamin supplements and NAC.

Publication types

  • Review

MeSH terms

  • Acetylcysteine / therapeutic use*
  • Alzheimer Disease / blood
  • Alzheimer Disease / cerebrospinal fluid
  • Alzheimer Disease / complications*
  • Alzheimer Disease / pathology
  • Cognition Disorders / blood
  • Cognition Disorders / cerebrospinal fluid
  • Cognition Disorders / drug therapy*
  • Cognition Disorders / etiology*
  • Free Radical Scavengers / therapeutic use*
  • Homocysteine / blood
  • Homocysteine / cerebrospinal fluid
  • Humans
  • Oxidative Stress
  • Plaque, Amyloid / pathology
  • Tetrahydrofolates / therapeutic use*
  • Vitamin B 12 / analogs & derivatives*
  • Vitamin B 12 / therapeutic use
  • Vitamin B Complex / therapeutic use

Substances

  • Free Radical Scavengers
  • Tetrahydrofolates
  • Homocysteine
  • Vitamin B Complex
  • mecobalamin
  • Vitamin B 12
  • 5-methyltetrahydrofolate
  • Acetylcysteine